Endocrine Abstracts

Background: Craniopharyngioma is a rare epithelial tumor of the central nervous system, affecting both children and adults and associated with significant morbidity.Objective: To study the potential differences in the clinical and radiological presentation of craniopharyngioma in children versus adults in a large mixed cohort.Material and methods: We performed a retrospective review of craniopharyngioma patients evaluated in the Na...

Introduction: Hashimoto’s thyroiditis (HT) is a well known risk factor for thyroid lymphoma. A rapidly enlarging goiter accompanied by lymph nodes pressure on surrounding structures usually suggest the development of thyroid lymphoma.Case report: An 85 years old hypertensive women presented for a massive goiter extending from the lower jaw to clavicle which increased in size for the last 5 months. She also complained of dysphagia, hoarseness and sho...

Introduction: Endogenous Cushing’s syndrome (CS) is a rare disease associated with severe morbidity and increased mortality if untreated. Glucose metabolism is significantly altered in hypercortisolism.Objective: To retrospectively analyse the clinical presentation of a cohort of patients with endogenous CS and study the frequency of glucose metabolism abnormalities as opposed to other clinical signs and symptoms.Material and ...

Background: Insulinomas, the most common functional neuroendocrine tumours of the pancreas, are usually sporadic, benign and solitary.Aims: To assess biochemical data, localisation and treatment outcome of insulinomas diagnosed in a tertiary endocrine centre.Patients and methods: Twenty-five patients (14 F/11 M), aged 49.1±14.1 years, diagnosed with insulinoma in a Neuroendocrine Tumours centre between 2000 and 2014 were retro...

Introduction: Testicular regression syndrome (TRS) or vanishing testis syndrome is a rare condition defined as the absence of testicular tissue in a genetic and phenotypic male. Rudimentary accessory structures can be present; in that case, the removal of all remnants is recommended.Case report: Male patient, 39 years old, had initially been evaluated at the age of 8 for persistent bilateral cryptorchidism. The medical documents are lacking except for a ...

Introduction: VD deficiency is associated with the atrophy of muscle fibres (predominantly type II). This leads to decreased muscle force and general physical performance.Objective: To analyse the relationship between the serum concentration of 25-hydroxy vitamin D (25OHD), balance and physical performance in women with VD deficiency and the effect of VD supplementation or treatment with a VD analog.Materials and methods: We analys...

Gingivitis is the most frequent periodontal manifestation during oral contraceptives therapy, mainly due to the altered oral bacterial flora under the influence of oestrogen and progesterone. The aim of this study was to investigate the influence of low-dose oral contraceptives on periodontal health in young females.Methods: 42 women aged 18–38 years without systemic disease, non-smokers, were divided in two study groups: 22 women treated with low-d...

Background: Low serum sodium levels were associated both in experimental studies and in clinical practice with increased prevalence of osteoporosis, due to decreased bone mineralization and increased osteoclastic activity. On the other hand, hyponatremia – independent of osteoporosis – is associated with fracture occurrence.Objectives: To assess the relationship between serum sodium levels and osteoporotic fractures.Patie...

Background: Pituitary adenomas (PA) are slow-growing, benign intracranial tumors. Rarely, they can be histologically and clinically aggressive.Aim: To present a case of corticotroph PA with aggressive behavior following a long indolent interval after the initial surgery.Case presentation: A 47 years old female presented in Nov 2007 with right temporal hemianopsia and left eye blindness, associating type 2 DM and severe mixed dyslip...

Background: Cushing’s disease is characterized by chronic ACTH hypersecretion, leading to hyperplasia of the adrenal zonae reticularis and fasciculata and, therefore, increased secretion of cortisol, androgens and DOC. Cushing’s disease is the most common form of Cushing’s syndrome, being responsible for approximately 80% of reported cases.Aim: To evaluate the curability rate of Cushing’s disease 1 year postoperatively.<p clas...